The Expression of Matrix Metalloproteinase-9 and Tumor Angiogenesis in Human Osteosarcoma
유진영, 정지한, 강석진, 최현주, 이안희, 서은주, 심상인, 강창석,
소속 상세정보
유진영 ( Yoo Jin-Young )
가톨릭대학교 의과대학 성빈센트병원 병리과
정지한 ( Jung Ji-Han )
가톨릭대학교 의과대학 성빈센트병원 병리과
강석진 ( Kang Seok-Jin )
가톨릭대학교 의과대학 성빈센트병원 병리과
최현주 ( Choi Hyun-Joo )
가톨릭대학교 의과대학 성빈센트병원 병리과
이안희 ( Lee An-Hi )
가톨릭대학교 의과대학 성빈센트병원 병리과
서은주 ( Seo Eun-Joo )
가톨릭대학교 의과대학 성빈센트병원 병리과
심상인 ( Shim Sang-In )
가톨릭대학교 의과대학 성빈센트병원 병리과
강창석 ( Kang Chang-Suk )
가톨릭대학교 의과대학 성빈센트병원 병리과
KMID : 0357920050390060418
Abstract
Background: Matrix metalloproteinase-9 (MMP-9) is a matrix-degrading enzyme that’s believed to play a crucial role not only for tumor invasion and metastasis, but also for a variety of stromal reactions, including neovascularization. The aim of this study was to investigate the expression of MMP-9 and to compare its expression with the angiogenesis activity in human osteosarcoma.
Methods: Archival tumor tissue samples from 20 patients with osteosarcoma were analyzed by performing immunohistochemistry for the expression of MMP-9 and CD34. The vascularity was measured as the average microvascular density (MVD) of the CD34-positive vessels. The clinical information was obtained through searching the computerized retrospective database from the tumor registry.
Results: MMP-9 was expressed in 90% (18/20) of the tumors we examined. The MVD ranged from 10.5 to 179.7 with a mean of 64.9. There was no significant correlation between the MMP-9 expression and the MVD (p=.613). The MMP-9 expression was not associated with any of the clinicopathologic variables, whereas the MVD showed an increasing tendency according to the metastasis status (p=.073).
Conclusions: We demonstrated that MMP-9 activation is likely to occur in human osteosarcoma. However, there was no direct involvement of MMP-9 with tumor angiogenesis. It is noteworthy that MVD may aid physicians to predict the presence of distant metastasis in osteosarcoma patients.
키워드
MMP-9;Angiogenesis;Osteosarcoma
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