외과적으로 절제한 폐의 편평세포암종과 샘암종에서 Anaphase Promoting Complex의 발현
Expression of Anaphase Promoting Complex in Surgically Resected Squamous Cell Carcinoma and Adenocarcinoma of the Lung
송지선, 강엽, 이상엽, 김호영, 정순희, 엄민섭, 박광하,
소속 상세정보
송지선 ( Song Ji-Sun )
관동대학교 의과대학 병리학교실
강엽 ( Kang Yup )
아주대학교 의과학연구소
이상엽 ( Yi Sang-Yeop )
관동대학교 의과대학 병리학교실
김호영 ( Kim Ho-Young )
연세대학교 원주의과대학 내과학교실
정순희 ( Jung Soon-Hee )
연세대학교 원주의과대학 병리학교실
엄민섭 ( Eum Min-Seob )
연세대학교 원주의과대학 병리학교실
박광하 ( Park Kwang-Hwa )
연세대학교 원주의과대학 병리학교실
KMID : 0357920060400010052
Abstract
Background: The anaphase promoting complex (APC) promotes the degradation of mitotic cyclins as well as other substrates involved in sister chromatid adhesion. This study was carried out to examine the relationship between the APC expression and the clinicopathological variables, in an attempt to determine the role of the APC in the proliferation of lung cancer and to evaluate the possibility of an aberrant APC function in surgically resected squamous cell carcinomas and adenocarcinomas of the lung.
Methods: Immunohistochemical staining was performed for APC, Ki-67, cyclin B1, Cdc2, MMP-2 and VEGF in 55 cases of squamous cell carcinoma and 34 cases of adenocarcinoma of the lung, using the avidin-biotin-peroxidase method.
Results: The immunohistochemical stains for APC revealed a positive reaction in 49 cases (55.1%). The APC expression level was higher in the cyclin B1-positive group (p= 0.01), the Cdc2-positive group (p=0.001), the MMP-2-positive group (p=0.03), the group with lymph node metastasis (61.4% vs 48.9%), and the group with stage II/III cancer (60.7%) compared
with those with stage I (42.9%).
Conclusions: The APC may have an aberrant function, such as a change in its role in controlling the cell cycle, and might be associated with the invasiveness and proliferation of tumor cells.
키워드
promoting complex;Squamous cell carcinoma;Adenocarcinoma;Lung cancer;Cell cycle
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