Expressions of Id-1 and Id-2 in Hyperplastic Thyroid Tissue and Thyroid Carcinoma
김영아, 김지은, 박도준, 박영주, 박성호,
소속 상세정보
김영아 ( Kim Young-A )
서울대학교 의과대학 보라매병원 병리과
김지은 ( Kim Ji-Eun )
서울대학교 의과대학 보라매병원 병리과
박도준 ( Park Do-Joon )
서울대학교 의과대학 내과학교실
박영주 ( Park Young-Joo )
서울대학교 의과대학 내과학교실
박성호 ( Park Seong-Hoe )
서울대학교 의과대학 병리학교실
KMID : 0357920060400010060
Abstract
Background: Id proteins are a family of helix-loop-helix proteins and are regarded to be negative regulators of cell differentiation. In general, Id-1 and Id-2 expressions are upregulated during tumor development and progression in a variety of neoplasms, and these expressions may be associated with aggressive tumor behavior. However, little is known about the roles of Id-1 and Id-2 in thyroid neoplasms.
Methods: The expressions of Id-1 and Id-2 were assessed immunohistochemically in 310 normal, hyperplastic, and neoplastic thyroid tissues using tissue microarrays.
Results: Normal thyroid tissues rarely expressed Id-1 or Id-2. Moreover, whilst Id-1 expression was more elevated in malignant thyroid tissue than in hyperplastic thyroid tissue, Id-2 expression was more variable. No significant differences were observed between histologic subtypes of thyroid carcinomas with respect to Id-1 or Id-2 expression. Follicular adenomas showed higher expressions of Id-1 and Id-2 than thyroid carcinomas. No significant association was found between clinicopathological parameters and Id-1 expression, though Id-2 expression was significantly reduced in metastatic, stage IV tumors.
Conclusion: The expressions of Id-1 and Id-2 were elevated in hyperplastic and neoplastic thyroid tissues. However, neither appears suitable as a marker of malignancy or an aggressive phenotype, although Id-2 expression in advanced thyroid carcinomas may reflect a favorable prognosis.
키워드
Inhibitor of differentiation protein 1;Inhibitor of differentiation protein 2;Thyroid gland;Carcinoma; papillary;Adenocarcinoma; follicular;Adenoma
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