Thyroid Papillary Carcinoma with Exuberant Nodular Fasciitis-like Stroma - A Case Report -
이경화, 이지신, 최찬, 윤정한, 정재훈, 민경환,
소속 상세정보
이경화 ( Lee Kyung-Hwa )
전남대학교 의과대학 병리학교실
이지신 ( Lee Ji-Shin )
전남대학교 의과대학 병리학교실
최찬 ( Choi Chan )
전남대학교 의과대학 병리학교실
윤정한 ( Yoon Jung-Han )
전남대학교 의과대학 외과학교실
정재훈 ( Chung Jae-Hun )
전남대학교 의과대학 병리학교실
민경환 ( Min Kyung-Whan )
미국 Deaconess Hospital Department of Pathology
KMID : 0357920060400010076
Abstract
Thyroid papillary carcinoma (TPC) with exuberant nodular fasciitis-like stroma is one of the rare variants of TPC. To date, only 19 cases have been reported in the English medical literature. We report here on the the first Korean case of TPC that contained a prominent nodular fasciitis-like stroma. A 40-year-old female presented with a hard painless right neck mass that had been present for two months. Total thyroidectomy disclosed a solitary nodule in the mid portion of the right lobe that measured 25×20 mm. The tumor was well delineated, but it was not encapsulated. Microscopically, the tumor was a typical papillary carcinoma except that large areas of the tumor were occupied by a stroma composed of irregular fascicular spindle cells. The stromal component accounted for 60% of the tumor mass. The spindle cells exhibited neither atypism nor mitosis, and the tumor’s extensive stromal cell proliferation resembled the appearance of nodular fasciitis of the soft tissues. Immunohistochemically, the spindle cells were positive for vimentin and -smooth muscle actin, but they were negative for thyroglobulin, thyroid transcription factor-1, S-100 protein, CD34 and desmin, and this represents
myofibroblastic features.
키워드
Thyroid neoplasms;Carcinoma;Papillary;Fasciitis
원문 및 링크아웃 정보
등재저널 정보