Enhanced CD24 Expression in Colorectal Cancer Correlates with Prognostic Factors
최윤라, Xuan Yan-Hua, 이상전, 박선미, 김원재, 김희진, 김석형,
소속 상세정보
최윤라 ( Choi Yoon-La )
성균관대학교 의과대학 삼성서울병원 병리학교실
( Xuan Yan-Hua )
연변대학교 의과대학 병리학과
이상전 ( Lee Sang-Jeon )
Chungbuk National University
박선미 ( Park Seon-Mee )
Chungbuk National University
김원재 ( Kim Wun-Jae )
Chungbuk National University
김희진 ( Kim Hee-Jin )
성균관대학교 의과대학 삼성서울병원 진단검사의학교실
김석형 ( Kim Seok-Hyung )
충북대학교 의과대학 병리학교실
KMID : 0357920060400020103
Abstract
Background: CD24 was originally described as a B cell-specific marker, however its aberrant expression in various solid tumors has recently been reported. Our objective was to determine the pattern and extent of the CD24 expression in colorectal cancer and its related lesions, and to clarify its correlation with clinico-pathological parameters and especially those associated with patients’ prognoses.
Methods: A total of 307 colorectal cancers and the related lesions (150 carcinomas, 30 high-grade adenomas, 49 low-grade adenomas, 41 hyperplastic polyps, and 37 normal colorectal epithelia) were immunohistochemically analyzed by treating CD24 monoclonal antibody onto tissue embedded paraffin blocks.
Results: CD24 expression was very rarely observed in the normal epithelia, hyperplastic polyps, and low-grade adenomas; however, in high-grade adenomas, the CD24 expression was shown to be mildly increased in the cytoplasm (13.3%). In carcinomas, the CD24 expression was increased substantially in both the membrane (38.0%) and the cytoplasm (44.7%). The expression of CD24 in the membrane was positively correlated with tumor size (p<0.01). The CD24 expression in the cytoplasm was positively correlated with several unfavorable parameters, including a larger tumor size (p<0.01), a higher tumor grade (p<0.01), a higher rate of tumor invasion (p<0.05), and a higher pTNM stage (p<0.05).
Conclusion: High levels of CD24 expression in the membrane and cytoplasm were characteristic in colorectal cancer, and the cytoplasmic CD24 expression was correlated with several unfavorable clinical parameters.
키워드
CD24;Colorectal neoplasm;Immunohistochemistry
원문 및 링크아웃 정보
등재저널 정보