Sinonasal Low-Grade Adenocarcinoma: Report of Three Cases with the Clinicopathologic and Immunohistochemical Findings
송준선, 강신광, 이봉재, 조경자, 허주령,
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송준선 ( Song Joon-Seon )
울산대학교 의과대학 서울아산병원 병리과
강신광 ( Khang Shin-Kwang )
울산대학교 의과대학 서울아산병원 병리과
이봉재 ( Lee Bong-Jae )
울산대학교 의과대학 서울아산병원 이비인후과학교실
조경자 ( Cho Kyung-Ja )
울산대학교 의과대학 서울아산병원 병리과
허주령 ( Huh Joo-Ryung )
울산대학교 의과대학 서울아산병원 병리과
KMID : 0357920060400030235
Abstract
Low-grade adenocarcinomas that primarily arise within the sinonasal tract are uncommon tumors. We report here on three cases of primary sinonasal low-grade adenocarcinomas. The patients were 2 females and 1 male with ages of 48, 57 and 64, respectively. Microscopically, the tumors had a well developed tubulopapillary growth pattern that consisted of columnar or pseudostratified cells with eosinophilic cytoplasm, round to oval nuclei and rare mitotic activity. On immunohistochemistry, the tumor cells were strongly positive for cytokeratin 7, but they were negative for cytokeratin 20, CDX-2 and p53. The Ki-67 labeling index was very low (mean: 1.9%). Two patients developed recurrent tumors at the primary site after the initial surgery, but all the patients are presently alive without metastasis 6 years 8 months, 8 years 8 months, and 11 months after the initial diagnosis. When considering the progress of these tumors, we think that it’s important to understand the pathology of this entity to avoid underdiagnosis because a complete excision is required for effective treatment.
키워드
Adenocarcinoma;Cytokeratin 7;Cytokeratin 20;CDX2 protein;p53;Ki-67 Antigen
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