파르보바이러스B19 감염에의한태아수종 - 부검2예보고-
Hydrops Fetalis Due to Parvovirus B19 Infection - Report of Two Autopsy Cases -
이호창, 지제근, 박성혜, 황필규, 이희은,
소속 상세정보
이호창 ( Lee Ho-Chang )
서울대학교 의과대학 병리학교실
지제근 ( Chi Je-Geun )
서울대학교 의과대학 병리학교실
박성혜 ( Park Sung-Hye )
서울대학교 의과대학 병리학교실
황필규 ( Hwang Pil-Gyu )
서울대학교 의과대학 병리학교실
이희은 ( Lee Hee-Eun )
서울대학교 의과대학 병리학교실
KMID : 0357920060400030245
Abstract
Hydrops fetalis (HF) is a disease characterized by generalized subcutaneous edema and cavity effusion in the fetal stage. We report here on two autopsy cases of HF that were caused by parvovirus B19 (PVB19) infection. The human PVB19 is an erythrovirus that cause diverse clinical manifestations ranging from an asymptomatic or mild presentation to more severe effects such as hydrops fetalis, and this is the only known human pathogenic parvovirus. The gestational ages of the two fetuses were 21 weeks and 23 weeks, respectively. Both fetuses were hydropic and anemic. Hepatic tissues of both fetuses demonstrated erythroblasts with eosinophilic intranuclear inclusions, the so called "lantern cells". PVB19 was confirmed by electron microscopy and immunohistochemical staining. For the diagnosis of this disease, recognition of parvovirus infection as a cause of hydrops fetalis and careful examination of red blood cells with a high-power view are required.
키워드
Anemia;Erythrovirus;Hydrops fetalis;Parvovirus B19
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