비소세포폐암종에서 Galectin-3 단백 발현의 의의
Significance of Galectin-3 Expression in Pulmonary Non-Small Cell Carcinoma
신동훈, 이창훈, 강현정, 설미영, 이민기,
소속 상세정보
신동훈 ( Shin Dong-Hoon )
부산대학교 의과대학 병리학교실
이창훈 ( Lee Chang-Hun )
부산대학교 의과대학 병리학교실
강현정 ( Kang Hyun-Jeong )
부산대학교 의과대학 병리학교실
설미영 ( Sol Mi-Young )
부산대학교 의과대학 병리학교실
이민기 ( Lee Min-Ki )
부산대학교 의과대학 내과학교실
KMID : 0357920060400050326
Abstract
Background: Non-small cell carcinoma (NSCC) has become the leading cause of cancer related death around the world. However, its prognostic factors remain poorly defined. Galectin-3 is an apoptosis related protein and its relationship with various cancers is presently the subject of research. This study was performed to investigate galectin-3 expression in NSCC and its value as a prognostic factor.
Methods: We examined the expression of galectin-3 and bcl-2 in surgically resected, lung NSCC, including 61 squamous cell carcinomas and 41 adenocarcinomas. PCNA staining was also performed.
Results: Each type of carcinoma showed cytoplasmic positivity in 18 (30.0%) and 25 (61.0%) cases, respectively. Squamous cell carcinoma showed increased galectin-3 expression in better differentiated tumors, whereas adenocarcinoma didn’t show any relationship with the degree of differentiation. The cytoplasmic positivity of galectin-3 in both types of carcinoma was associated with poor prognosis. Bcl-2 expression didn’t show any significant relationship with overall survival. Galectin-3 and bcl-2 expressions were positively correlated. However, co-expression of both proteins was not related to prognosis.
Conclusions: These results indicate that galectin-3 expression in NSCC warrants attention as a possible prognostic factor.
키워드
Non small cell lung carcinoma;Galectin 3
원문 및 링크아웃 정보
등재저널 정보