소기도 질환의 임상 특성 및 병리학적 판독
Small Airway Diseases: Clinical Characteristics and Pathological Interpretation
권건영, 고성민, 최원일,
소속 상세정보
권건영 ( Kwon Kun-Young )
계명대학교 의과대학 병리학교실
고성민 ( Ko Sung-Min )
계명대학교 의과대학 진단방사선과
최원일 ( Choi Won-Il )
계명대학교 의과대학 내과학교실
KMID : 0357920060400060389
Abstract
Small airway diseases are seen in many clinical conditions. The locations of small airway diseases are small bronchioles including terminal and respiratory bronchioles, and alveolar duct. The histopathologic features of bronchiolar injury have been described variously and have led to confusing and overlapping terms. The purpose of this article is to describe the clinical characteristics and histopathologic interpretation of small airway diseases. We classify the small airway diseases as primary bronchiolar diseases, and secondary bronchiolar diseases including pulmonary parenchymal diseases, and large airway diseases with prominent bronchiolar involvement. Primary bronchiolar diseases include respiratory bronchiolitis, acute bronchiolitis, constrictive bronchiolitis, follicular bronchiolitis, diffuse panbronchiolitis, mineral dust airway diseases, and a few other variants. Pulmonary parenchymal diseases with bronchiolar involvement include respiratory bronchiolitis-associated interstitial lung disease, organizing pneumonia, hypersensitivity pneumonitis, pulmonary Langerhans’ cell histiocytosis, sarcoidosis and idiopathic pulmonary fibrosis. Bronchiolar changes can also be seen in large airway diseases such as chronic bronchitis, bronchiectasis, cystic fibrosis and asthma. The patterns of bronchiolar response to various injuries are relatively limited and these patterns are generally non-specific in regard to the etiology. Appropriate interpretation and diagnosis of small airway diseases depend on judicious correlation of clinical, radiologic, and histopathologic characteristics.
키워드
Small airway disease;Primary bronchiolar disease;Secondary bronchiolar disease;Tobacco-related disease
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