Clinicopathological Analysis of Systemic Anaplastic Large Cell Lymphoma
정수영, 류한석, 고재수, 류백열, 이승숙,
소속 상세정보
정수영 ( Jung Soo-Young )
원자력병원 병리학과
류한석 ( Ryu Han-Suk )
원자력병원 병리학과
고재수 ( Koh Jae-Soo )
원자력병원 병리학과
류백열 ( Ryoo Baek-Yeol )
원자력병원 혈액종양내과
이승숙 ( Lee Seung-Sook )
원자력병원 병리학과
KMID : 0357920060400060399
Abstract
Background: Several studies from western countries have reported variable prognoses for patients with systemic anaplastic large cell lymphoma (ALCL) depending strongly on the expression of anaplastic lymphoma kinase (ALK). However, no prognostic significance of ALK expression in Koreans was reported in a single report regarding these patients, although the number of cases was limited in that study.
Methods: We analyzed the clinicopathological features of ALK+ ALCL and ALK- ALCL in 30 Korean patients diagnosed with primary systemic ALCL.
Results: ALK expression was detected in 60% of all ALCL patients (18/30), and there was no statistical significance to ALK expression in overall survival. Patients with ALK+ ALCL were younger in age and had negative bcl-2 expression; these differences were statistically significant. Tumors positive for ALK protein and granzyme B expression, and negative for bcl-2 expression with a null-cell phenotype tended to have better survival outcomes, althought this trend failed to reach statistical significance (p<0.2), probably due to the limited number of cases inthis study.
Conclusion: ALK protein expression and the absence of bcl-2 in tumor cells tend to result in better survival despite the failure of this trend to achieve statistical significance. Further studies that examine potential pathologic prognostic factors combined with the expression of ALK and apoptotic factors such as bcl-2 are needed. Additional larger-scale studies are also needed to conclude that ALK expression has no prognostic significance among Koreans.
키워드
Lymphoma; large-cell;Ki-1;Anaplastic lymphoma kinase;bcl-2; proto-oncogene proteins
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