p53, Heat Shock Protein 70 and Topoisomerase II Expression in Gallbladder Carcinoma
김대철, 노미숙, 정진숙,
소속 상세정보
김대철 ( Kim Dae-Cheol )
동아대학교 의과대학 병리학교실
노미숙 ( Roh Mee-Sook )
동아대학교 의과대학 병리학교실
정진숙 ( Jeong Jin-Sook )
동아대학교 의과대학 병리학교실
KMID : 0357920060400060432
Abstract
Background: The present study was designed to investigate the expression of p53, Heat Shock Protein 70 (HSP70), and Topoisomerase (Topo) IIα in the preneoplastic lesions and carcinomas of the gallbladder (GB) and to assess the correlation between the expression of these proteins and the clinicopathologic parameters by performing immunohistochemistry.
Methods: The immunohistochemical expressions of p53, HSP70 and Topo IIα were evaluated in 38 gallbladder carcinomas and 3 adenomas. Fifteen CISs and 8 dysplasias that were located adjacent to invasive carcinomas were also studied.
Results: A p53 expression was identified in 22 (57.9%) of the 38 GB carcinomas, in 9 (64.3%) of 14 CISs, and in none of the 8 dysplasias and 3 adenomas. A HSP70 expression was found in 11 (29%) of the 38 carcinomas, in 11 (78.6%) of 14 CISs, and in 4 (57.2%) of 7 dysplasias. A Topo IIα expression was present in 36 (94.7%) of the 38 carcinomas, in 13 (92.9%) of 14 CISs, in 7 (100%) of 7 dysplasias and in 3 (100%) of 3 adenomas. p53 overexpression was related to the T stage of the primary tumor, while HSP70 and Topo IIα were not related to any of the clinicopathologic para- meters.
Conclusion: p53 may be involved in GB carcinogenesis and in the progression of cancer. p53 may be also helpful for making the differential diagnosis between dysplasia and CIS. A further large study is needed to better elucidate the roles of HSP70 and Topo IIα in GB carcinogenesis.
키워드
Gallbladder;Carcinoma;p53;Heat shock protein 70;DNA topoisomerase II alpha
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