Immunohistochemical Profile of Acute Cellular Rejection in Renal Allograft
박종하, 변승운, 박수길, 유은실, 조영미, 한덕종,
소속 상세정보
박종하 ( Park Jong-Ha )
울산대학교 의과대학 서울아산병원 내과학교실
변승운 ( Byun Seung-Woon )
울산대학교 의과대학 서울아산병원 내과학교실
박수길 ( Park Su-Kil )
울산대학교 의과대학 서울아산병원 내과학교실
유은실 ( Yu Eun-Sil )
울산대학교 의과대학 서울아산병원 병리과
조영미 ( Cho Yong-Mee )
울산대학교 의과대학 서울아산병원 병리과
한덕종 ( Han Duck-Jong )
울산대학교 의과대학 서울아산병원 일반외과
KMID : 0357920070410010015
Abstract
Background : We wanted to find an adjunctive marker(s) in renal allograft biopsies for predicting acute cellular rejection (ACR), and so the expression patterns of immune-related molecules were compared between ACR, borderline ACR and non-ACR cases.
Methods : The expression patterns of Fas ligand (FasL), HLA-DR, granzyme B, caspase-3, CD56, interferon stimulated growth factor-3 (ISGF-3), and CD53 were assessed via immunohistochemical study in 75 allograft biopsies from patients with ACR (n=19), borderline ACR (n=22), and non-ACR (n=34).
Results : Compared to those of the non-ACR group, the ACR group revealed an elevated number of FasL positive interstitial inflammatory cells, HLA-DR positive tubular inflammatory cells, cytoplasmic caspase-3 positive tubular epithelial cells, granzyme B positive interstitial mononuclear inflammatory cells and CD53 positive interstitial inflammatory cells. The expression patterns of the borderline ACR group were similar to those of non-ACR group, except for the intensity of FasL in the tubular epithelial cells.
Conclusions : Immunohistochemical investigations of the adjunctive markers FasL, HLA-DR, granzyme B, caspase-3 and CD56 can be useful for making the diagnosis of ACR.
키워드
Renal transplantation; Graft rejection; Cellular immunity; Immunohistochemistry
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