신 이형성증에서 PAX2 발현
PAX2 Expression in Renal Dysplasia
이윤희, 정우희, 홍순원, 정현주,
소속 상세정보
이윤희 ( Lee Yoon-Hee )
연세대학교 의과대학 병리학교실
정우희 ( Jung Woo-Hee )
연세대학교 의과대학 병리학교실
홍순원 ( Hong Soon-Won )
연세대학교 의과대학 병리학교실
정현주 ( Jeong Hyeon-Joo )
연세대학교 의과대학 병리학교실
KMID : 0357920070410020069
Abstract
Background: Renal dysplasia is the abnormal development of the kidney. The condition is usually detected in childhood along with other urinary tract anomalies, but can remain unnoticed until adulthood. It was recently reported that a PAX2 gene mutation plays a major role in the development of renal dysplasia. The aim of this study was to examine the expression of PAX2 in dysplastic kidneys of children and adults.
Methods: A total of 30 cases diagnosed with renal dysplasia after a nephrectomy were examined. PAX2 expression was evaluated using immunohistochemistry. Apoptosis was detected using an Apop Tag detection kit.
Results: In the dysplastic kidneys, there was strong PAX2 expression in the epithelia of the primitive ducts in both children and adults, but the degree was significantly lower in adults (p=0.007). However, the mesenchyme surrounding the primitive ducts of children showed stronger staining for the smooth muscle actin antibody and trichrome than the adults. The apoptosis index was significantly higher in the primitive duct epithelia than in the surrounding normal collecting duct epithelia (p=0.000).
Conclusion: PAX2 is overexpressed in the primitive ducts of renal dysplasia, which is sustained until adulthood and is associated with increased apoptosis. However, a decrease in PAX2 expression in the dysplastic epithelia and mesenchymal cuff of adults suggest a gradual regression of the dysplastic elements with time.
키워드
PAX2; Renal dysplasia; Apoptosis; Adult
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