수모세포종에서 Vimentin과 Survivin의 표현율과 예후와의 관계
Vimentin and Survivin Expression Rates as Prognostic Factors in Medulloblastoma
석재연, 김세훈, 이윤희, 권지은, 김태승,
소속 상세정보
석재연 ( Seok Jae-Yeon )
연세대학교 의과대학 병리학교실
김세훈 ( Kim Se-Hoon )
연세대학교 의과대학 병리학교실
이윤희 ( Lee Yoon-Hee )
연세대학교 의과대학 병리학교실
권지은 ( Kwon Ji-Eun )
연세대학교 의과대학 병리학교실
김태승 ( Kim Tai-Seung )
연세대학교 의과대학 병리학교실
KMID : 0357920070410020087
Abstract
Background: A medulloblastoma is a primitive neuroepithelial tumor of the cerebellum that occurs in children and metastasizes through the cerebrospinal fluid. It is highly malignant and invasive, and the 5-year survival rate is only 60%. Surgical resection techniques, radiation, and chemotherapy have improved the overall survival but the patients suffer life-long cognitive dysfunctions or endocrine abnormalities as the side effects of treatment. Therefore it is essential to identify prognostic markers to determine the appropriate treatment strategy in order to minimize the side effects.
Methods: This study evaluated the immunohistochemical differentiation and survival rate with synaptophysin, glial fibrillary acidic protein, epithelial membrane antigen, vimentin and primitive neuroepithelial marker nestin of 55 paraffin-embedded medulloblastomas, using a tissue microarray. The expression of survivin, the apoptotic inhibitor, and the survival rate with regard to the proliferation index of Ki-67 were also investigated.
Results: The group testing positive to vimentin, a mesenchymal differentiation marker, had a worse prognosis and there was a strong correlation between vimentin expression and nestin expression. Patients with a survivin expression rate >35% had a significantly poorer clinical course and there was a correlation between the survivin expression rate and Ki-67 expression rate.
Conclusion: In conclusion, vimentin and survivin are negative prognostic markers in medulloblastomas.
키워드
Medulloblastoma; Vimentin; Nestin; Survivin; Prognosis
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