비소세포폐암종에서 p73의 발현
Expression of p73 in Non-small Cell Lung Carcinomas
정지한, 최현주, 유진영, 강석진, 이교영, 박경신, 정찬권,
소속 상세정보
정지한 ( Jung Gee-Han )
가톨릭대학교 의과대학 임상병리과학교실
최현주 ( Choi Hyun-Joo )
가톨릭대학교 의과대학 임상병리과학교실
유진영 ( Yoo Jin-Young )
가톨릭대학교 의과대학 병리학교실
강석진 ( Kang Seok-Jin )
가톨릭대학교 의과대학 병리학교실
이교영 ( Lee Kyo-Young )
가톨릭대학교 의과대학 병리학교실
박경신 ( Park Gyeong-Sin )
가톨릭대학교 의과대학 병리학교실
정찬권 ( Jung Chan-Kwon )
가톨릭대학교 의과대학 임상병리학과
KMID : 0357920070410020109
Abstract
Background: The p73 is a recently identified homologue of the tumor suppressor gene, p53, and it has been found to induce apoptosis and inhibit cell proliferation. However, its role in the development of tumors is unclear. This study examined the expression of p73 in patients with non-small cell lung carcinomas (NSCLCs) to determine its clinical significance and association with the expressions of p53, pRb, and mdm2.
Methods: A total of 183 NSCLCs were analyzed immunohistochemically using a tissue microarray.
Results: The p73 protein was expressed in the cell nuclei in 156 (85.2%) out of the 183 cases. There was no correlation between the p73 expression and the clinicopathological variables. However, there was a correlation between the p73 expression and the mdm2 and pRb expressions. Multivariate Cox survival analysis identified tumor size and lymph node metastasis to be independent prognostic factors, but the p73 expression was not found to be associated with the patients‘ survival.
Conclusion: p73 is commonly expressed in NSCLC and it might, in conjunction with pRb and mdm2, be involved in the development of these tumors.
키워드
p73; Carcinoma; Non-small cell lung; Prognosis
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