위암에서 예후인자로서 점액소 표현형과 CDX2 단백 발현의 역할
Mucin Phenotype and CDX2 Expression as Prognostic Factors in Gastric Carcinomas
정찬권, 이교영, 최명규, 송교영, 박조현, 박경신, 홍영선,
소속 상세정보
정찬권 ( Jung Chan-Kwon )
가톨릭대학교 의과대학 임상병리학교실
이교영 ( Lee Kyo-Young )
가톨릭대학교 의과대학 임상병리학교실
최명규 ( Choi Myung-Gyu )
가톨릭대학교 의과대학 내과학교실
송교영 ( Song Kyo-Young )
가톨릭대학교 의과대학 외과학교실
박조현 ( Park Cho-Hyun )
가톨릭대학교 의과대학 외과학교실
박경신 ( Park Gyeong-Sin )
가톨릭대학교 의과대학 병리학교실
홍영선 ( Hong Young-Seon )
가톨릭대학교 의과대학 내과학교실
KMID : 0357920070410030139
Abstract
Background : Mucin phenotypic markers and CDX2 are widely expressed in gastric carcino- mas, however, recent studies have produced conflicting results regarding whether the expression patterns of these markers have clinicopathologic significance.
Methods : We examined samples from 217 gastric carcinoma patients immunohistochemically to determine if the expression of mucin phenotypic markers and CDX2 was correlated with postoperative survival and other clinicopathologic factors.
Results : All tumors were phenotypically classified as gastric (type G, 81 cases), gastric and intestinal mixed (type GI, 55 cases), intestinal (type I, 43 cases), or unclassified (type U, 38 cases). The occurrence of type G and GI tumors was positively correlated with tumor progression whereas that of type U tumors was negatively correlated with tumor progression. CDX2 expression was correlated with type I tumors. Tumors that expressed MUC5AC or MUC6 had a better prognosis than those that did not. When the relationship bet- ween phenotype and prognosis was considered, type GI had the best prognosis, followed by type G, then type U.
Conclusions : The mucin phenotypic markers may be useful for predicting tumor progression and survival in patients with gastric carcinomas. Additionally, CDX2 may play an important role in gastric carcinogenesis of type I tumors.
키워드
Mucin Phenotype and CDX2 Expression as Prognostic Factors in Gastric Carcinomas
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