Reduced Expression of Claudin-7 Correlates with Invasiveness and Nuclear Grade of Breast Carcinomas
석상희, 황순휘, 강수환, 이수정, 배영경,
소속 상세정보
석상희 ( Seok Sang-Hee )
영남대학교 의과대학 병리학교실
황순휘 ( Hwang Sun-Hwi )
영남대학교 의과대학 예방의학교실
강수환 ( Kang Soo-Hwan )
영남대학교 의과대학 외과학교실
이수정 ( Lee Soo-Jung )
영남대학교 의과대학 외과학교실
배영경 ( Bae Young-Kyung )
영남대학교 의과대학 병리학교실
KMID : 0357920070410030158
Abstract
Background : Claudins are important components of the tight junctions in the intercellular barriers and cell polarity. Among them, claudin-7 is down-regulated in breast cancers compared with the normal breast epithelium. The aim of this study was to determine the expression pattern and prognostic value of claudin-7 in breast carcinomas.
Methods : Claudin-7 expression was evaluated immunohistochemically in 42 cases of ductal carcinoma in situ (DCIS) and in 142 cases of invasive breast carcinoma (IBC) using a tissue microarray (TMA).
Results : Claudin- 7 was strongly expressed in the normal luminal epithelial cells in the breast lobule. The level of claudin-7 expression was significantly lower or absent in 45.2% (19/42) of DCIS and 72.5% (103/142) of IBC. A loss or reduced expression of claudin-7 correlated with the invasiveness (p=0.001) of breast carcinomas and a high nuclear grade (p=0.013) in IBC.
Conclusion: Claudin-7 is an important tight junction protein in the breast and a loss of expression may assist in the dissociation and invasion of tumor cells.
키워드
Claudin-7;Breast cancer;Immunohistochemistry;Microarray analysis
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