위샘암 환자의 예후 인자로서 Thymosin- 4의 유용성
Prognostic Significance of Thymosin- 4 in Gastric Adenocarcinoma Patients
김루시아, 한지영, 김준미, 주영채, 박인서, 김예지, 최석진,
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김루시아 ( Kim Lucia )
인하대학교 의과대학 병리학교실
한지영 ( Han Jee-Young )
인하대학교 의과대학 병리학교실
김준미 ( Kim Joon-Mee )
인하대학교 의과대학 병리학교실
주영채 ( Chu Young-Chae )
인하대학교 의과대학 병리학교실
박인서 ( Park In-Suh )
인하대학교 의과대학 병리학교실
김예지 ( Kim Ye-Ji )
인하대학교 의과대학 병리학교실
최석진 ( Choi Suk-Jin )
인하대학교 의과대학 병리학교실
KMID : 0357920070410030176
Abstract
Background : Thymosin- 4 is an actin-sequestering protein that regulates actin polymerization. It is known to be associated with cell migration, angiogenesis and wound healing, as well as with tumor metastasis.
Methods : We immunohistochemically evaluated the thymosin- 4 expression in gastric adenocarcinoma specimens, the relationship between this protein and the pathologic features and other tumor-related proteins, and its influence on the patient outcome.
Results : We demonstrated that 40 specimens (26.3%) of 152 gastric adenocarcinomas showed positivity for thymosin- 4. The thymosin- 4 expression was statistically associated with advanced tumor stage (p=0.010), the nodal stage (p=0.029), the TNM stage (p=0.008), and the presence of lymphovascular invasion (p=0.009). The thymosin- 4 protein expression was closely related to the positivity for VEGF (p=0.000), c-Myc (p=0.007), and cyclin D1 (p=0.005), but it was not associated with the E-cadherin (p=0.861) or -catenin (p=0.640) expressions. The median survival and disease relapse time of patients showing thymosin-4 immunoreactivity were statistically shorter than those of patients without expression. Multivariate analysis showed that the tumor stage (p=0.003), nodal stage (p=0.005), thymosin- 4 expression (p=0.019) and Lauren’s classification (p=0.037) were statistically important prognostic factors for gastric adenocarcinomas.
Conclusions : The thymosin- 4 expression might be associated with disease progression of gastric adenocarcinomas and it should be regarded as an important prognostic factor for estimating patient survival.
키워드
Stomach cancer;Thymosin-beta4;Metastasis;Survival
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