Epstein-Barr virus-associated Inflammatory Pseudotumor-like Follicular Dendritic Cell Tumor in the Spleen of a Patient with Diffuse Large B Cell Lymphoma: A Case Report and Review of the Literature
윤선옥, 고형석, 김백희, 권기영, 전윤경, 김철우,
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윤선옥 ( Yoon Sun-Och )
서울대학교 의과대학 병리학교실
고형석 ( Ko Hyoung-Suk )
서울대학교 의과대학 병리학교실
김백희 ( Kim Baek-Hee )
서울대학교 의과대학 병리학교실
권기영 ( Kwon Ghee-Young )
성균관대학교 의과대학 삼성서울병원 병리학교실
전윤경 ( Jeon Yoon-Kyung )
서울대학교 의과대학 병리학교실
김철우 ( Kim Chul-Woo )
서울대학교 의과대학 병리학교실
KMID : 0357920070410030198
Abstract
We report a case of an Epstein-Barr virus (EBV)-associated inflammatory pseudotumor-like follicular dendritic cell tumor (IPT-like FDC tumor). The tumor occurred in the spleen of a 64-year-old woman with a history of a diffuse large B-cell lymphoma (DLBCL) of neck nodes that presented four years ago. The splenectomy specimen revealed a 5 cm-sized, tan-colored and well-circumscribed mass. Histologically, spindle or ovoid cells with large vesicular nuclei were admixed with abundant inflammatory cells. Immunohistochemically, spindle cells were positive for FDC marker CD35, but negative for CD20, CD30 and ALK. EBV was detected almost ex- clusively in spindle cells by EBER in situ hybridization. IPT-like FDC tumors are rare, and are recognized as a distinctive clinicopathologic variant of FDC tumors. Among only 18 similar cases reported in the English language literature, the present case is the first case of a patient with a history of DLBCL.
키워드
Inflammatory pseudotumor;Follicular dendritic cell tumor;Spleen;Neoplasm;Epstein-Barr virus
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