샘창자 위화생과 나이, 샘창자궤양, 헬리코박터의 관계
Relationship of Gastric Metaplasia of the Duodenum with Age, Duodenal Ulcer and Helicobacter pylori Infection
송대현, 이정희, 윤희상, 고경혁, 김동철, 김현진, 이종실,
소속 상세정보
송대현 ( Song Dae-Hyun )
경상대학교 의학전문대학원 병리학교실
이정희 ( Lee Jeong-Hee )
경상대학교 의과대학 병리학교실
윤희상 ( Youn Hee-Sang )
경상대학교 의과대학 소아과학교실
고경혁 ( Ko Gyung-Hyuck )
경상대학교 의학전문대학원 병리학교실
김동철 ( Kim Dong-Chul )
경상대학교 의학전문대학원 병리학교실
김현진 ( Kim Hyun-Jin )
경상대학교 의학전문대학원 내과학교실
이종실 ( Lee Jong-Sil )
경상대학교 의과대학 병리학교실
KMID : 0357920070410040217
Abstract
Background :Gastric metaplasia of the duodenum is thought to be associated with the pathogenesis of duodenal ulcer. We investigated the pathological features of gastric metaplasia and their relation to age, gender, duodenal ulcer and H. pylori infection.
Methods :We reviewed the duodenal endoscopic findings of 535 patients (age range: 0 to 87) and the microscopic
slides of the duodenal biopsy specimens.
Results : Gastric metaplasia was first noted at the age of 4 and the prevalence increased thereafter until the patients’ mean age reached about 30. The prevalence of gastric metaplasia was 53.7% after 30 years of age. As the metaplasia became severer, it became more polypoid in appearance and it more often contained
parietal cells. Gastric metaplasia was more frequently observed or severe in duodenal ulcer patients, in males and in the first portion of the duodenum than in patients without duodenal ulcer, in females and in the second portion, respectively. There was a lack of correlation between gastric metaplasia and H. pylori infection.
Conclusions :The prevalence and/or severity of gastric metaplasia of the duodenum increases with age, and it is thought that most duodenal
ulcers develop in the areas of gastric metaplasia.
키워드
Gastric metaplasia;Duodenal ulcer;Helicobacter pylori
원문 및 링크아웃 정보
등재저널 정보