유방 병변의 악성 진행에 따른 Survivin 단백 발현
Expression of Survivin According to Malignant Progression of Breast Lesions
최현주, 이교영, 강창석, 정찬권, 정지한, 유진영, 강석진, 이은정,
소속 상세정보
최현주 ( Choi Hyun-Joo )
가톨릭대학교 의과대학 임상병리학교실
이교영 ( Lee Kyo-Young )
가톨릭대학교 의과대학 임상병리학교실
강창석 ( Kang Chang-Suk )
가톨릭대학교 의과대학 임상병리학교실
정찬권 ( Jung Chan-Kwon )
가톨릭대학교 의과대학 임상병리학교실
정지한 ( Jung Ji-Han )
가톨릭대학교 의과대학 임상병리학교실
유진영 ( Yoo Jin-Young )
가톨릭대학교 의과대학 임상병리학교실
강석진 ( Kang Seok-Jin )
가톨릭대학교 의과대학 임상병리학교실
이은정 ( Lee Eun-Jung )
가톨릭대학교 의과대학 임상병리학교실
KMID : 0357920070410040238
Abstract
Background :The aim of this study was to examine the survivin expression pattern in benign lesions, atypical ductal hyperplasias (ADH), ductal carcinomas in situ (DCIS) and in invasive carcinomas of the breast and to evaluate the effect of expression of this marker on the malignant progression of breast cancers. In addition, the relationship between the expression of the marker and the clinicopathological characteristics for invasive carcinomas were investigated.
Methods :Immunohistochemical staining using a tissue microarray method for survivin was performed for 103 benign lesions, 30 ADHs, 26 DCISs and 116 invasive carcinomas.
Results :The expression of cytoplasmic survivin was higher for invasive carcinomas than for ADHs and DCISs (p<0.05). For breast invasive carcinomas, expression of cytoplasmic survivin significantly correlated with tumor size, lymph node metastasis and stage (p<0.05).
Conclusions :These results suggest that overexpression of cytoplasmic survivin may be involved in the development of the late stage of breast malignancy, especially invasiveness. In breast invasive carcinomas, expression of survivin may be a useful indicator for the evaluation of patient prognosis.
키워드
Breast; Survivin; Immunohistochemistry
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