암색전의 맥관 내 맥관 형성에 관한 면역조직화학적 연구
An Immunohistochemical Study of Angiogenesis in Tumor Emboli
김조헌, 이지신, 최찬, 정상우, 이제혁, 김성순, 한창우,
소속 상세정보
김조헌 ( Kim Jo-Heon )
전남대학교 의과대학 병리학교실
이지신 ( Lee Ji-Shin )
전남대학교 의과대학 병리학교실
최찬 ( Choi Chan )
전남대학교 의과대학 병리학교실
정상우 ( Juhng Sang-Woo )
전남대학교 의과대학 병리학교실
이제혁 ( Lee Jae-Hyuk )
전남대학교 의과대학 병리학교실
김성순 ( Kim Sung-Sun )
전남대학교 의과대학 병리학교실
한창우 ( Han Chang-Woo )
전남대학교 의과대학 병리학교실
KMID : 0357920070410040252
Abstract
Background : Angiogenesis, which is essential for tumor growth, is known to occur in the extravascular stroma. However, vascular structures were noted in intravascular tumor emboli in surgical specimens. This prompted our investigation of the frequency and morphology of angiogenesis in tumor emboli.
Methods : Hematoxylin-eosin stained specimens were reviewed for tumor emboli, in 21 cases of stomach adenocarcinoma and 22 cases of colon adenocarcinoma. The cases were examined with immunohistochemistry using antibodies against epithelial antigen (cytokeratin), endothelial antigens (CD31, CD34), lymphatic endothelial antigen (D2-40), and proliferation-associated antigen (MIB1).
Results : Endothelial cells were observed in 16 tumor emboli among four (19.1%) of the 21 cases of stomach adenocarcinoma and in 32 tumor emboli among four (18.2%) of the 22 cases of colon adenocarcinoma. The endothelial cells in the tumor emboli showed papillary ingrowth from the vessel wall, formation of vascular lumens, scattered distribution, or surface coating of the emboli. Some of the endothelial cells in the tumor emboli were D2-40-positive, and some were MIB1- positive.
Conclusions : These findings demonstrated that angiogenesis occurs in intravascular tumor emboli as well as in the extravascular stroma. Angiogenesis in the tumor emboli may reflect an active process and may facilitate tumor growth.
키워드
Angiogenesis;Tumor emboli;Immunohistochemistry
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