초자-혈관형 Castleman병의 특이한 간질 풍부 변종 - 1예 보고 -
An Unusual Stroma-Rich Variant of Castleman’s Disease of the Hyaline-Vascular Type - A Case Report -The stroma-rich variant of Castleman’s disease of the hyaline-vascular type (CDHV) is a rare
정지한, 이교영, 박경신, 최현주, 유진영, 강석진, 박경신,
소속 상세정보
정지한 ( Jung Ji-Han )
가톨릭대학교 의과대학 임상병리학교실
이교영 ( Lee Kyo-Young )
가톨릭대학교 의과대학 임상병리학교실
박경신 ( Park Gyeong-Sin )
가톨릭대학교 의과대학 병리학교실
최현주 ( Choi Hyun-Joo )
가톨릭대학교 의과대학 임상병리학교실
유진영 ( Yoo Jin-Young )
가톨릭대학교 의과대학 임상병리학교실
강석진 ( Kang Seok-Jin )
가톨릭대학교 의과대학 임상병리학교실
박경신 ( Park Gyeong-Sin )
가톨릭대학교 의과대학 임상병리학교실
KMID : 0357920070410040266
Abstract
The stroma-rich variant of Castleman’s disease of the hyaline-vascular type (CDHV) is a rare entity that shows overgrowth of a variety of stromal cells in the widened interfollicular (IF) area. We report here on a case of a stroma-rich variant of CDHV in an 18-year-old man who presented with an asymptomatic solitary neck mass he’d had for 1 year. Histologically, an enlarged lymph node fulfilled the criteria of CDHV, along with vague nodularity of a widened IF area. The nodular lesion consisted of numerous vessels and a proliferation of spindle cells. Immunohistochemically, the spindle cells were positive for vimentin and smooth muscle actin, they were negative for desmin, CD21, CD34, CD68, ALK-1, and S-100 protein. This stromal lesion is typically hyperplastic and clinically benign, and it must be distinguished from neoplastic stromal proliferation associated with Castleman’s disease because of its potential for recurrence and metastasis.
키워드
Castleman’s disease;Angiofollicular lymphoid hyperplasia;Stroma cells
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