Ki-1 Positive Extranodal NK/T Cell Lymphoma, Nasal Type, Mistaken as Dermatomyositis - A Case Report and Literature Review -
김현정, 김정연, 신은아, 박경미, 유영진, 이승숙,
소속 상세정보
김현정 ( Kim Hyun-Jung )
인제대학교 의과대학 상계백병원 병리학교실
김정연 ( Kim Jung-Yeon )
인제대학교 의과대학 상계백병원 병리학교실
신은아 ( Shin Eun-Ah )
인제대학교 의과대학 상계백병원 병리학교실
박경미 ( Park Kyeong-Mee )
인제대학교 의과대학 상계백병원 병리학교실
유영진 ( Yoo Young-Jin )
인제대학교 의과대학 상계백병원 진단검사의학과
이승숙 ( Lee Seung-Sook )
국립암센터 병리과
KMID : 0357920070410040278
Abstract
We report a case of a 38-year-old male with extranodal NK/T-cell lymphoma, nasal type, showing unusual clinical and pathological features. The patient was admitted for soft tissue swelling and tenderness in both legs. The patient had been treated intermittently 8 months prior for repeated muco-cutaneous ulcers. A muscle biopsy showed medium-sized atypical lymphoid cells with bizarre nuclei and plump cytoplasm, infiltrating to the skeletal muscle fibers with angiocentricity. The immunoresults were Ki-1+, CD56+, cytoplasmic CD3+, with EBV-in situ hybridization +. The patient rapidly deteriorated and died of sepsis and respiratory failure shortly after initiation of low-dose chemotherapy. A careful review of previous biopsies revealed scarce atypical lymphoid cells around vessels with similar immunoprofiles without the presence
of Ki-1 positive cells. This case emphasizes that an extranodal NK/T-cell lymphoma may have a dermatomyositis-like diffuse presentation. Ki-1 co-expression can be an unexpected event in a process of the disease course; however, this should be validated with future studies.
키워드
Extranodal NK/T-cell lymphoma;nasal type;Dermatomyositis;Ki-1
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