Genetic Expression Pattern of Gastric Carcinomas According to Cellular Mucin Phenotypes
이원애, 유완식, 배한익, 서인수, Li Ying-Hua, 엄지현,
소속 상세정보
이원애 ( Lee Won-Ae )
단국대학교 의과대학 병리학교실
유완식 ( Yu Wan-Sik )
경북대학교병원 외과
배한익 ( Bae Han-Ik )
경북대학교병원 해부병리과
서인수 ( Suh In-Soo )
단국대학교 의과대학 병리학교실
( Li Ying-Hua )
단국대학교 의과대학 병리학교실
엄지현 ( Eum Ji-Hyun )
단국대학교 의과대학 병리학교실
KMID : 0357920070410050307
Abstract
Background : Gastric carcinomas (GCs) have recently been reclassified according to the mucin phenotypes. We aimed to characterize the relationship between the mucin phenotypes and the genetic alterations or the clinicopathologic parameters of GCs.
Methods : Immunohistochemistry was performed for MUC1, MUC5AC, MUC6, MUC2, CD10, p53, hMLH1, C-erbB2 and E-cadherin in 150 GCs. The mucin phenotypes of the GCs were classified as 4 phenotypes: gastric, intestinal, mixed and unclassified.
Results : MUC1, MUC5AC, MUC6, MUC2 and CD10 were expressed in 63.3%, 42.7%, 14.0%, 24.7% and 14.0% of the GCs, respectively. The mucin phenotypes of the GCs corresponded to the gastric type in 31.3%, the intestinal type in 20.0%, the mixed type in 15.3% and the unclassified type in 33.3%. The incidence of a p53 overexpression was higher in the gastric or mixed phenotype than in the intestinal or unclassified phenotype. MUC5AC expression, p53 overexpression and the gastric or mixed phenotype were associated with poor patient survival by multivariate analysis.
Conclusion : This study suggests the gastric or mixed mucin phenotype may more likely go through the p53 pathway in carcinogenesis and the mucin phenotype may be considered as a prognostic indicator.
키워드
Stomach;Carcinoma;Mucins;TP53 protein;hMLH1 protein;ERBB2 protein;Ecadherin
원문 및 링크아웃 정보
등재저널 정보