상부 요로상피세포암종에서 Twist의 발현이 환자의 무병 생존에 미치는 영향 및 종양 등급과의 연관성
wist Expression in Upper Urinary Tract Urothelial Carcinoma Affects Patients Disease Free Survival and is Associated with Tumor Grade
김동일, 문경철, 윤선옥, 김보미, 강경훈, 박석연,
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김동일 ( Kim Dong-Il )
서울대학교 의과대학 병리학교실
문경철 ( Moon Kyung-Chul )
서울대학교 의과대학 병리학교실
윤선옥 ( Yoon Sun-Och )
서울대학교 의과대학 병리학교실
김보미 ( Kim Bo-Mi )
서울대학교 의과대학 병리학교실
강경훈 ( Kang Gyeong-Hoon )
서울대학교 의과대학 병리학교실
박석연 ( Park Seog-Yun )
서울대학교 의과대학 병리학교실
KMID : 0357920070410050324
Abstract
Background : Epithelial-mesenchymal transition (EMT) is critical for morphogenesis during embryonic development and is also implicated in the conversion of early-stage tumors into invasive malignancies.
Recently, Twist has been identified to play an important role in EMT-mediated metastatic progression of several types of human cancer. The present study examined the expression of Twist and evaluated its clinicopathologic significance in urothelial carcinoma of upper urinary tract.
Methods : Immunohistochemical staining for Twist expression was performed on 70 upper urinary tract urothelial carcinomas (UUT-UCs) using tissue microarray.
Results : Immunohistochemical staining for Twist was positive in 31/70 cases (44.3%) of UUT-UCs. Twist expression was associated with high-grade and advanced-stage (ISUP grade, p<0.01; stage, p=0.045). The patients with Twist positive-tumors revealed lower disease free survival rate than those with Twist negative-tumors (p<0.01). The overall survival for patients with Twist positive-tumors was slightly worse than the patients with Twist negative-tumors, but the difference was not statistically significant (p=0.12).
Conclusion : Our results suggest that Twist is a novel marker for advanced UUT-UC.
키워드
Carcinoma;transitional cell;Twist transcription factor;Disease free survival
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