Adenocarcinoma with Yolk Sac Tumor of the Stomach: Case Report with Review of the Literature and an Immunohistochemical Study
홍란, 이미자, 서재홍,
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홍란 ( Hong Ran )
조선대학교 의과대학 병리학교실
이미자 ( Lee Mi-Ja )
조선대학교 의과대학 병리학교실
서재홍 ( Suh Chae-Hong )
조선대학교 의과대학 병리학교실
KMID : 0357920070410050352
Abstract
Gastric yolk sac tumors are extremely rare with only a few cases reported in the literature. Here, we present the case of a 50-year-old man with an adenocarcinoma and a yolk sac tumor of the stomach, without metastasis to the lymph nodes. The tumor was an early gastric carcinoma confined to the submucosa. Twelve months post-operation the patient was alive with no complications. The yolk sac tumor showed positive labeling for -fetoprotein (AFP), 1-antitrypsin (1-AT), cytokeratin (CK) and carcinoembryonic antigen (CEA), but was negative for human chorionic gonadotrophin (hCG), placental alkaline phosphatase (PLAP), epithelial membrane antigen (EMA) and p53. The adenocarcinoma was positive for 1-AT, CK, EMA, and CEA, but was negative for AFP, hCG, PLAP, and p53. These findings suggest that the yolk sac tumor and the adenocarcinoma components are closely related and may represent distinct phenotypes that arise from a common mucosal epithelial cell.
키워드
Stomach;Yolk sac tumor;Adenocarcinoma;Immunohistochemistry
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