비소세포 폐암종의 상피성장인자 수용체 상태와 임상-병리학적 연관성: 단백 발현, 유전자 증폭 및 생존분석
Clinicopathologic Analysis of Epidermal Growth Factor Receptor Status in Non-small Cell Lung Cancer: Protein Expression, Gene Amplification and Survival Analysis
이승구, 최진, 장세진,
소속 상세정보
이승구 ( Lee Sung-Koo )
강원대학교 병리과
최진 ( Choi Jene )
울산대학교 의과대학 서울아산병원 병리과
장세진 ( Jang Se-Jin )
울산대학교 의과대학 병리학교실
KMID : 0357920070410060387
Abstract
Background : Abnormal over-expression or gene amplification of epidermal growth factor receptor (EGFR) is important in the prognosis of non-small cell lung cancer (NSCLC). We investigated the frequency of EGFR protein expression and gene amplification, and the correlation between EGFR status and survival in NSCLC.
Methods : We examined 360 cases of microarrayed NSCLC tissues for the EGFR protein expression and EGFR gene amplification using immunohistochemistry and fluorescent in situ hybridization.
Results : EGFR protein expression and EGFR gene amplification occurred in 110 cases (30.6%) and 24 cases
(6.7%), respectively. EGFR prote in expression and gene amplification were more frequent in squamous cell carcinoma than in adenocarcinoma. Differences in EGFR protein expression did not dramatically affect survival curves (p=0.740), but differences in gene amplification did (p<0.05): EGFR gene amplification was associated with a lower 5-year survival rate.
Conclusion : EGFR protein expression and gene amplification showed moderate correlation with each other. EGFR gene amplification predicted a poor prognosis, whereas EGFR protein expression did not.
키워드
Carcinoma;Non-small-cell lung;Receptor;Epidermal growth factor;In situ hybridization
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