원발성 침윤성 소엽암종으로 오진한 유방으로 전이된 갑상샘 수질암종- 1예 보고 -
Metastatic Medullary Carcinoma of Thyroid to Breast; A CaseInitially Diagnosed as Primary Invasive Lobular Carcinoma-A Case Report-
이영석, 안준석, 김철환, 염범우, 최종상, 채양석,
소속 상세정보
이영석 ( Lee Young-Seok )
고려대학교 안암병원 병리과
안준석 ( An Jung-Suk )
고려대학교 안암병원 병리과
김철환 ( Kim Chul-Hwan )
고려대학교 안암병원 병리과
염범우 ( Yeom Bom-Woo )
고려대학교 안암병원 병리과
최종상 ( Choi Jong-Sang )
고려대학교 안암병원 병리과
채양석 ( Chae Yang-Seok )
고려대학교 안암병원 병리과
KMID : 0357920070410060412
Abstract
Metastasis to the breast from medullary carcinoma of the thyroid is extremely rare. We report a case of metastatic medullary carcinoma of the thyroid which presented as multiple breast masses with ipsilateral axillary lymphadenopathy in a 48-year-old woman. Six years ago, she underwent total thyroidectomy and neck dissection because of palpable neck masses, with a diagnosis of medullary thyroid carcinoma. Histological features of breast masses showed single-file or linear-cord arrangements, with plasmacytoid appearance, and the initial diagnosis was invasive lobular carcinoma. She underwent modified radical mastectomy. The tumor cells were diffusely positive for E-cadherin, calcitonin and thyroid transcription factor-1 (TTF-1) and were metastatic medullary carcinoma of thyroid. In the patients with a history of medullary carcinoma of the thyroid, a careful examination is necessary for a breast mass composed of solid and cord-like clusters of small round to ovoid cells with plasmacytoid appearance. Immunohistochemical staining for E-cadherin, calcitonin and TTF-1 could be helpful for differential diagnosis.
키워드
Medullary carcinoma;Thyroid;Breast;Metastasis;Invasive lobular carcinoma
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