유방암 환자에게서 관찰된 Cytokeratin 탐식 조직구에 의한 감시 림프절의 거짓전이- 1예 보고 -
Pseudometastasis in Sentinel Lymph Nodes with Cytokeratin Debris-containing Histiocytes in Breast Cancer Patient- A Case Report -
최금하, 차은정, 최하나, 문우성,
소속 상세정보
최금하 ( Choi Keum-Ha )
전북대학교 의학전문대학원 병리학교실
차은정 ( Cha Eun-Jung )
전북대학교 의학전문대학원 병리학교실
최하나 ( Choi Ha-Na )
전북대학교 의학전문대학원 병리학교실
문우성 ( Moon Woo-Sung )
전북대학교 의학전문대학원 병리학교실
KMID : 0357920070410060427
Abstract
Immunohistochemical staining for cytokeratins can detect false negative nodes in patients with breast carcinoma. We report on a patient with breast carcinoma and pseudometastasis detected by immunohistochemical staining within a negative sentinel lymph node. A 66-year-old woman underwent a simple mastectomy and sentinel lymph node biopsy. Immunohistochemical staining of the sentinel nodes for cytokeratin in permanent sections showed cells with intense cytoplasmic staining in the subcapsular sinus. The cells were negative for epithelial membrane antigen staining, but positive for CD68. In combination with morphologic findings and immunohistochemistry, cytokeratin-positive cells were confirmed as histiocytes with phagocytized cytokeratin debris. Careful correlation with histology and additional IHC could help avoid a misinterpretation of this type of pseudometastasis.
키워드
Breast;Sentinel lymph node biopsy;Cytokeratin;Histiocytes;Pseudometastasis
원문 및 링크아웃 정보
등재저널 정보