Adrenocortical Carcinoma, Myxoid Variant - A Case Report -
김보미, 홍은경, 윤선옥, 김동일, 국명철,
소속 상세정보
김보미 ( Kim Bo-Mi )
서울대학교병원 병리학교실
홍은경 ( Hong Eun-Kyung )
국립암센터 병리과
윤선옥 ( Yoon Sun-Och )
서울대학교병원 병리학교실
김동일 ( Kim Dong-Il )
서울대학교병원 병리학교실
국명철 ( Kook Myung-Cherl )
국립암센터 병리과
KMID : 0357920070410060430
Abstract
Myxoid variant of adrenal cortical carcinoma is extremely rare and there have been only 16 such cases reported in the medical literature. Here we report on a case of 43-year-old woman with a left adrenal mass that was detected during the evaluation for Cushing’s syndrome. Left adrenalectomy was performed and the tumor weighed 347 g. The cut surface was predominantly myxoid and gelatinous with central hemorrhage and necrosis. Histologically, the tumor cells were rather small, uniform and polygonal with mild pleomorphism. It showed diverse morphologic patterns according to the amount of the myxoid stromal component. Making the diagnosis was not easy because the tumor was without areas of conventional adrenocortical carcinoma. Immunohistochemically, the tumor cells were positive for -inhibin, synaptophysin and vimentin, but the tumor cells were negative for pan-cytokeratin and CAM 5.2. The immunophenotypes were identical to those of conventional adrenal cortical neoplasms. During the evaluation of a cytokeratin-negative and vimentin-positive retroperitoneal neoplasm with a myxoid component, the possibility of adrenal cortical tumor should be considered in spite that this is a very rare entity.
키워드
Adrenocortical carcinoma;Myxoid;Cushing syndrome
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