양성 및 악성 갑상샘 병변에서의 galectin-3, skp2, p27, cyclin D1 발현의 연관성
Correlation of Expression of galectin-3, skp2, p27 and cyclin D1 in Benign and Malignant Thyroid Lesions
홍순억, 홍민의, 권귀영, 김미경,
소속 상세정보
홍순억 ( Hong Soon-Auck )
중앙대학교 의과대학 병리학교실
홍민의 ( Hong Min-Eui )
중앙대학교 의과대학 병리학교실
권귀영 ( Kwon Gui-Young )
중앙대학교병원 병리과
김미경 ( Kim Mi-Kyung )
중앙대학교 의과대학 병리학교실
KMID : 0357920080420030134
Abstract
Background : The overexpression of cyclin D1 and galectin-3 and the loss of p27 in thyroid cancers have recently been reported by many studies. The S-phase kinase associated protein 2 (skp2) plays an important role in the degradation of p27. We compared the correlation of the expressions of galectin-3, p27, cyclin D1 and skp2 in thyroid lesions.
Methods : Sixty five cases were included in this study and immunohistochemical staining for galectin-3, skp2, p27 and cyclin D1 was performed.
Results : The expression of galectin-3 increased in the order of nodular hyperplasia, follicular adenoma, follicular carcinoma and papillary carcinoma (p<0.01). The expression rate of skp2 was 0% for nodular hyperplasia, 16.7% for follicular adenoma, 33.3% for follicular carcinoma and 16.7% for papillary carcinoma. The loss of the expression of p27 was more frequently detected in papillary carcinoma as compared with nodular hyperplasia (p<0.01). The increased expression of cyclin D1 was noted in follicular adenoma and carcinoma as compared with nodular hyperplasia (p=0.043). The expression of galectin-3 was related with the loss of a p27 expression (p<0.01), and the expression of skp2 was related with the expression of the cyclin D1 (p=0.022).
Conclusion : Galectin-3 appears to be the most useful marker for making the diagnosis of thyroid lesions. The loss of a p27 expression can help differentiate nodular hyperplasia and papillary carcinoma, and the determining the expression of cyclin D1 may be helpful for the differential diagnosis of nodular hyperplasia and follicular neoplasm.
키워드
Galectin-3; skp2; p27; Cyclin D1; Thyroid cancer
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