위암에서 Epstein-Barr Virus 연관성의 예측 인자
Predictive Factors of Epstein-Barr Virus Association in Gastric Adenocarcinoma
김영수, 남상철, 한만훈, 정지윤, 서인수, 박선균, 배한익,
소속 상세정보
김영수 ( Kim Young-Su )
경북대학교 의과대학 병리학교실
남상철 ( Nam Sang-Chul )
경북대학교 의과대학 병리학교실
한만훈 ( Han Man-Hoon )
경북대학교 의과대학 병리학교실
정지윤 ( Jeong Ji-Yun )
경북대학교 의과대학 병리학교실
서인수 ( Suh In-Soo )
경북대학교 의과대학 병리학교실
박선균 ( Park Sun-Kyun )
경북대학교 의과대학 예방의학교실
배한익 ( Bae Han-Ik )
경북대학교 의과대학 병리학교실
KMID : 0357920080420040193
Abstract
Background: It is important to detect Epstein-Barr virus (EBV) in the setting of gastric cancer so that early viral targeted therapy and prevention can be undertaken. The aim of this study was to investigate the predictive clinicopathologic factors for EBV-related gastric cancer.
Methods: The archival tumor tissues from 335 patients with gastric cancer were examined using tissue microarray. The detection of EBV was performed using EBV mRNA in situ hybridization (EBV-ISH), and the results were compared against clinicopathologic factors.
Results: EBV-related gastric cancers were identified in 21 of 335 investigated cases (6.27%). The anatomical predisposition of EBV-related cancers to manifest in the upper stomach was statistically significant (p<0.001). EBV-related cancers were almost always (20/21) accompanied by lymphoid stroma. No differences in age, sex, histologic differentiation, or T or N stage were noted between EBV-positive and EBV-negative gastric carcinomas.
Conclusions: The association of EBV with gastric adenocarcinomas could be predicted when tumors with lymphoid stroma occurred in the upper stomach.
키워드
Epstein-Barrvirus;Gastriccancer
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