미세먼지와 보통형 간질폐렴의 상관 관계
Birefringent Particles as an Effective Factor in Usual Interstitial Pneumonia
김민정, 하승연, 정성환, 신봉경,
소속 상세정보
김민정 ( Kim Min-Jung )
가천의과학대학교 길병원 병리과학교실
하승연 ( Ha Seung-Yeon )
가천의대 길병원 병리과
정성환 ( Jeong Sung-Hwan )
가천의과학대학교 길병원 내과학교실
신봉경 ( Shin Bong-kyung )
고려대학교 구로병원 병리과
KMID : 0357920080420040198
Abstract
Background: It has long been recognized that birefringent paticles (BP) are associated with pulmonary disease. And there is increasing evidence that BP cause fibrotic reaction within the lung depending on both particle size and composition.
Methods: We collected 41 cases of usual interstitial pneumonia (UIP) and 101 cases of normal lung tissue from control group including squamous cell carcinoma, adenocarcinoma and bullae. BPs in the 0.1 to 10 μm size range under polarizing microscope was measured and counted by image analyzer.
Results: BP counts are mean 244.05/10 HPF in UIP and 71.4/10 HPF in control group. BPs in UIP is three times more than control (p=0.000). It increased significantly by the age of patients (p= 0.000).
Conclusions: BPs in lung might be important cause of inflammation and fibrosis in UIP.
키워드
Pneumonias;interstitial;Polarizationmicroscopy;Dust
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