간세포암종에서 -catenin의 핵 내 발현과 임상병리적 인자들과의 관계
Correlation of the Nuclear β-catenin Expression with the Clinicopathological Parameters of Hepatocellular Carcinoma
곽형종, 박호성, 장규윤, 문우성, 이동근, 강명재, 최금하, 최하나, 정명자, 황성호,
소속 상세정보
곽형종 ( Gwak Hyeong-Jong )
전북대학교 의과대학 병리학교실
박호성 ( Park Ho-Sung )
전북대학교 의과대학 병리학교실 및 의과학연구소
장규윤 ( Jang Kyu-Yun )
전북대학교 의과대학 병리학교실 및 의과학연구소
문우성 ( Moon Woo-Sung )
전북대학교 의과대학 병리학교실 및 의과학연구소
이동근 ( Lee Dong-Geun )
전북대학교 의과대학 병리학교실 및 의과학연구소
강명재 ( Kang Myoung-Jae )
전북대학교 의과대학 병리학교실 및 의과학연구소
최금하 ( Choi Keum-Ha )
전북대학교 의학전문대학원 병리학교실
최하나 ( Choi Ha-Na )
전북대학교 의학전문대학원 병리학교실
정명자 ( Chung Myoung-Ja )
전북대학교 의학전문대학원 전북대학교병원 병리학교실
황성호 ( Hwang Sung-Ho )
전북대학교 의학전문대학원 병리학교실
KMID : 0357920080420040208
Abstract
Background: Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the human liver. However, the molecular changes and mechanisms that regulate the development and progression of HCC remain unclear. Beta-catenin is known as a multi-functional protein that acts as a regulator of the cadherin-mediated cell-cell adhesion system and also in the Wingless/Wnt signal transduction pathway. The aim of this study was to investigate the expression of β-catenin and its possible role in HCC.
Methods: We investigated the expression of β-catenin, Ki-67, TP53, α-smooth muscle actin and CD34 by performing immunohistochemical staining for 61 specimens of HCC and their adjacent non-tumorous tissue. We also examined the relationship between the nuclear expression of β-catenin and the clinicopathologic parameters.
Results: The altered expression of β-catenin was not detected in the non-tumorous liver tissue. The nuclear expression of β-catenin was observed in approximately 16% (10/61) of the HCC specimens. Double immunohistochemical staining for β-catenin and E-cadherin showed a close relationship between nuclear translocation of β-catenin and the loss of the membranous E-cadherin expression. Significant correlation was found between the nuclear translocation of β-catenin and the tumor size, tumor necrosis and the presence of microvessel invasion and intrahepatic metastasis (p<0.05).
Conclusions: This data indicates that nuclear translocation of β-catenin could play a role in the growth and progression of HCC.
키워드
Carcinoma;Hepatocellular;Betacatenin;Cellnucleus;Immunohistochemistry
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