Expression of Claudin-1, p53 and E-cadherin in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma of the Head and Neck
최금하, 박호성, 장규윤, 이동근, 이호, 권근상, 문우성, 정명자, 은재순, 임재홍, 이주형,
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최금하 ( Choi Keum-Ha )
전북대학교 의학전문대학원 병리학교실
박호성 ( Park Ho-Sung )
전북대학교 의과대학 병리학교실 및 의과학연구소
장규윤 ( Jang Kyu-Yun )
전북대학교 의과대학 병리학교실 및 의과학연구소
이동근 ( Lee Dong-Geun )
전북대학교 의과대학 병리학교실 및 의과학연구소
이호 ( Lee Ho )
전북대학교 의과대학 법의학교실
권근상 ( Kwon Keun-Sang )
전북대학교 의과대학 예방의학교실
문우성 ( Moon Woo-Sung )
전북대학교 의학전문대학원 병리학교실
정명자 ( Chung Myoung-Ja )
전북대학교 의학전문대학원 전북대학교병원 병리학교실
은재순 ( Eun Jae-Soon )
우석대학교 약학대학
임재홍 ( Lim Jae-Hong )
전북대학교 의과대학 병리학교실
이주형 ( Lee Ju-Hyung )
전북대학교 의과대학 예방의학교실
KMID : 0357920080420050287
Abstract
Background : Pseudoepitheliomatous hyperplasia (PEH) is a reactive proliferation of surface epithelium and can be confused with invasive squamous cell carcinoma (SCC) in head and neck biopsy specimens. To distinguish PEH from invasive SCC, immunohistochemical staining for claudin-1, E-cadherin and p53 was performed.
Methods : Eighteen cases of PEH and 29 invasive SCC from head and neck lesions were immunostained and examined.
Results : The invasive SCC showed increased staining of claudin-1 (p<0.001) and p53 (p<0.001) and decreased staining of E-cadherin (p=0.005) compared to the PEH specimens. The combined score calculated by adding the positive sum of claudin-1 and p53 and subtracting E-cadherin was useful for the differentiation of SCC from PEH (89.7% sensitivity and 88.9% specificity, p<0.001).
Conclusions : The combined immunostaining for claudin-1, p53 and E-cadherin may help differentiate PEH from invasive SCC. The results of this study suggest that the increased expression of claudin-1 and p53 and the decreased expression of E-cadherin maybe markers for the aggressive growth of invasive SCC.
키워드
Hyperplasia;Carcinoma;squamous cell;Claudin-1;p53 protein;E-cadherin
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