방광의 요로상피암종에서 p16, Rb, FHIT 단백 발현에 대한 연구
Expression of p16, Rb and FHIT Proteins in Urothelial Carcinoma of the Urinary Bladder
한선희, 안준석, 이주한, 이응석, 김영식, 김서희,
소속 상세정보
한선희 ( Han Sun-Hee )
고려대학교 의과대학 안산병원 병리학교실
안준석 ( An Jung-Suk )
고려대학교 의과대학 병리학교실
이주한 ( Lee Ju-Han )
고려대학교 의과대학 안산병원 병리학교실
이응석 ( Lee Eung-Seok )
고려대학교 의과대학 안산병원 병리학교실
김영식 ( Kim Young-Sik )
고려대학교 의과대학 안산병원 병리학교실
김서희 ( Kim Seo-Hee )
고려대학교 의과대학 안산병원 병리학교실
KMID : 0357920080420050294
Abstract
Background : The goal of this study was to investigate the expression of p16, retinoblastoma (Rb) and fragile histidine triad (FHIT) proteins in urothelial carcinomas of the urinary bladder, and to evaluate the relationship between clinicopathlogic parameters and each protein expression level.
Methods : The expression of p16, Rb, and FHIT proteins were studied in 176 patients with urothelial carcinoma of the urinary bladder by immunohistochemistry.
Results : The diffuse positive expression of the p16 protein was significantly associated with high grade and advanced tumor depth (p=0.007 and p=0.020). The loss of the Rb protein was significantly associated with old age and disease recurrence (p=0.020 and 0.037). The loss of the FHIT protein was significantly associated with advanced tumor depth (p=0.002).
Conclusions : Our data suggest that p16 and FHIT proteins may be involved in the progression of urothelial
carcinoma. In addition, p16 may be a useful prognostic marker for individual urothelial carcinoma patients.
키워드
Bladder cancer;p16INK4A protein;Retinoblastoma protein;FHIT protein
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