위의 상피 형성이상과 샘암종에서 Galectin-3와 Galectin-7의 발현
The Expression of Galectin-3 and Galectin-7 in Epithelial Dysplasia and Adenocarcinoma of the Stomach
곽지은, 김한성, 주미, 장선희, 심상화, 이혜란,
소속 상세정보
곽지은 ( Kwak Ji-Eun )
인제대학교 의과대학 일산백병원 병리과
김한성 ( Kim Han-Seong )
인제대학교 의과대학 일산백병원 병리과
주미 ( Joo Mee )
인제대학교 의과대학 일산백병원 병리과
장선희 ( Chang Sun-Hee )
인제대학교 의과대학 일산백병원 병리과
심상화 ( Shim Sang-Hwa )
인제대학교 의과대학 일산백병원 병리과
이혜란 ( Lee Hye-Ran )
인제대학교 의과대학 일산백병원 내과학교실
KMID : 0357920080420060365
Abstract
Background : Galectin-3 and galectin-7 may play roles in human carcinogenesis. The aim of this study was to investigate the expressions of galectin-3 and galectin-7 in gastric dysplasia and adenocarcinoma.
Methods : We examined the expressions of galectin-3, galectin-7, and P53 in nonneoplastic gastric mucosa, gastric epithelial dysplasia (GED), and adenocarcinoma by immunohistochemistry. Twenty cases of nonneoplastic gastric mucosa, 20 cases of low grade GED, 20 cases of high grade GED, 40 cases of early gastric cancer (EGC), and 60 cases of advanced gastric cancer (AGC) are included for study.
Results : In the nonneoplastic tissue, only galectin-3 was expressed in the intestinal metaplasia. Galectin-7 was not stained in the nonneoplastic gastric mucosa. Galectin-3 was expressed in 3 cases of low grade GED (15%), 13 cases of high grade GED (65%), 2 cases of EGC (5%), and 5 cases of AGC (8%), respectively. Galectin-7 was expressed in 2 cases of low grade GED (10%), 3 cases of high grade GED (15%), and 4 cases of EGC (10%), respectively. However, it was not expressed in AGC.
Conclusions : Based on our results, the expressions of galectin-3 and galectin-7 may contribute to the development of gastric epithelial dysplasia and early gastric cancer, rather than contributing to the progression of gastric adenocarcinoma.
키워드
Galectins; Galectin 3; Adenoma; Adenocarcinoma; Stomach
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