유방의 화생성 편평상피세포암종 17예에 대한 임상 및 병리학적 분석
Metaplastic Squamous Carcinoma of the Breast: Clinicopathologic Analysis of 17 Cases
이선아, 이경은, 문병인, 한운섭, 성순희,
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이선아 ( Lee Sun-Ah )
이화여자대학교 의과대학 병리학교실
이경은 ( Lee Kyong-Eun )
이화여자대학교 의과대학 내과학교실
문병인 ( Moon Byung-In )
이화여자대학교 의과대학 외과학교실
한운섭 ( Han Woon-Sub )
이화여자대학교 의과대학 병리학교실
성순희 ( Sung Sun-Hee )
이화여자대학교 의과대학 병리학교실
KMID : 0357920090430010020
Abstract
Background: Squamous cell carcinoma of the breast is very rare and it is considered to arise from metaplastic change of ductal carcinoma. Metaplastic squamous cell carcinoma (MSC) of the breast includes pure squamous cell carcinoma, metaplastic adenosquamous carcinoma and low grade adenosquamous carcinoma. Most of the cases of MSC of the breast were reported to have lymph node metastasis and this has a worse prognosis than that of conventional
invasive ductal carcinoma.
Methods: We collected 17 cases of MSC of the breast from 1,173 cases of breast cancer and analyzed the clinicopathological characteristics.
Results: The age range was 31 to 69 years (mean age: 47.2). The mean tumor size was 3.6 cm. Twelve cases (70.6%) had a negative nodal status. The majority of the cases were of a high nuclear grade (grade III: 76.5%), and a high histologic grade (grade III: 88.2%). All the cases had no amplification of HER2, and they were negative for hormonal receptors, except for 2 cases withn weak positivity. All the cases showed positivity for EGFR (3+: 14 cases, 1+: 3 cases). Clinical relapse was found in 3 patients on follow up and two of them expired due to lung and bone metastasis.
Conclusions: MSC is associated with high nuclear and histologic grades, a high EGFR expression and they are triple negative for ER, PR, and HER2. The EGFR immunopositivity of MSC suggests a basal-like subtype.
키워드
Breast cancer;Squamous cell carcinoma;Epidermal growth factor receptor;TP63 protein;human
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