Gastric Adenocarcinoma with Coexistent Hepatoid Adenocarcinoma and Neuroendocrine Carcinoma -A Case Report-
김애리, 김성운, 송선교, 배영경,
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김애리 ( Kim Ae-Ri )
영남대학교 의과대학 병리학교실
김성운 ( Kim Sung-Woon )
영남대학교 의과대학 외과학교실
송선교 ( Song Sun-Kyo )
영남대학교 의과대학 외과학교실
배영경 ( Bae Young-Kyung )
영남대학교 의과대학 병리학교실
KMID : 0357920090430010079
Abstract
This report represents a very rare case of a gastric adenocarcinoma that was coexistent with hepatoid adenocarcinoma and neuroendocrine carcinoma. A 77-year-old man was admitted to our hospital due to a huge ulcerofungating mass identified at the proximal body of the stomach. After a pathological diagnosis of the tumor as a poorly differentiated adenocarcinoma was made, the patient underwent a total gastrectomy with lymph node dissection. Microscopically, the tumor consisted of three morphologically distinct components-tubular adenocarcinoma, hepatoid adenocarcinoma and neuroendocrine carcinoma. The hepatoid adenocarcinoma component resembled a hepatocellular carcinoma and produced alpha-fetoprotein. The neuroendocrine carcinoma component was positive for chromogranin and synaptophysin immunostains. This is an example of the diverse morphological and immunophenotypical differentiation of gastric carcinomas.
키워드
Gastric cancer;AFP;Hepatocellular carcinoma;Neuroendocrine carcinoma
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