The Expression of Cyclooxygenase-2 and Survivin in Urinary Bladder Transitional Cell Carcinoma
장석용, 이경섭,
소속 상세정보
장석용 ( Jang Suk-Yong )
동국대학교 의과대학 병리학교실
이경섭 ( Lee Kyung-Seob )
동국대학교 의과대학 비뇨기과학교실
KMID : 0357920090430030206
Abstract
Background: The aim of this study was to investigate the expressions of cyclooxygenase-2 (COX-2) and survivin in bladder transitional cell carcinoma (TCC) that has different clinicopathologic characteristics, and we also wanted to determine if a relation exists between the COX-2 and survivin expressions.
Methods: The expressions of COX-2 and survivin were investigated in 80 bladder TCCs by performing immunohistochemistry.
Results: The normal bladder mucosa did not express COX-2 and survivin. COX-2 immunopositivity and cytoplasmic survivin immunopositivity were seen in 48% and 30% of bladder tumors, respectively. The expressions of COX-2 and survivin were closely related to the differentiation, depth and recurrence of bladder TCC, and there was a significant correlation in topographic distribution of COX-2 and survivin immunopositivity. In addition, COX-2 and survivin were predominantly expressed at the invasive front of tumors.
Conclusions: This data suggest that COX-2 and survivin may be involved in the progression of bladder TCC, and there is a close correlation between the expressions of COX-2 and survivin.
키워드
Bladder cancer;Cyclooxygenase-2;Survivin
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