The Expressions of E2F1 and p53 in Gastrointestinal Stromal Tumorsand Their Prognostic Significance
권미정, 남은숙, 조성진, 박혜림, 신형식, 이종석, 박찬흔, 신운건,
소속 상세정보
권미정 ( Kwon Mi-Jung )
한림대학교 의과대학 병리학교실
남은숙 ( Nam Eun-Suk )
한림대학교 의과대학 병리학교실
조성진 ( Cho Seong-Jin )
한림대학교 의과대학 병리학교실
박혜림 ( Park Hye-Rim )
한림대학교 의과대학 병리학교실
신형식 ( Shin Hyung-Sik )
한림대학교 의과대학 병리학교실
이종석 ( Lee Jong-Seok )
한림대학교 의과대학 강동성심병원 외과학교실
박찬흔 ( Park Chan-Heun )
한림대학교 의과대학 강동성심병원 외과학교실
신운건 ( Shin Woon-Geon )
한림대학교 의과대학 내과학교실
KMID : 0357920090430030212
Abstract
Background: E2F1 plays a critical role in the G1-to-S phase transition by inducing various genes that encode S phase-activating proteins and that modulate such diverse cellular functions as DNA synthesis, mitosis and apoptosis. The purpose of this study was to assess the E2F1 expression in relation to the clinicopathologic parameters and other tumor markers in gastrointestinal stromal tumors.
Methods: Immunohistochemical stainings for obtaining the E2F1, p53, and Ki-67 labeling indices were performed on a tissue microarray of 72 gastrointestinal stromal tumor specimens. The clinicopathologic parameters that were analyzed including the risk grade system by Miettinen et al. and the disease-free survival (DFS) rate.
Results: 1) An E2F1 expression was correlated with a larger tumor size, a p53 expression and a shorter period of DFS (p=0.014, p=0.007, and p=0.039). 2) A p53 expression was significantly associated with a high risk grade, a larger tumor size, high mitotic counts and a shorter period of DFS (p=0.003, p=0.044, p<0.001, and p<0.0001). 3) A high-risk grade and the epithelioid type were significantly associated with a shorter period of DFS (p=0.0006 and p=0.0008).
Conclusions: E2F1, as well as p53, may be a potentially novel independent prognostic factor for predicting a worse outcome for those patients suffering with Gastrointestinal stromal tumors.
키워드
Gastrointestinal stromal tumor;E2F1 transcription factor;Ki-67 antigen;Tumor suppressor protein p53;Immunohistochemistry
원문 및 링크아웃 정보
등재저널 정보