악성림프종에서 SV40 Large T Antigen의 검색
Detection of SV40 Large T Antigen in Malignant Lymphomas
김영아, 장미수, 백진호, 윤선옥, 전윤경, 김철우, 김지은,
소속 상세정보
김영아 ( Kim Young-A )
서울대학교 의과대학 보라매병원 병리과
장미수 ( Chang Mee-Soo )
서울대학교 의과대학 보라매병원 병리과
백진호 ( Paik Jin-Ho )
서울대학교 의과대학 병리학교실
윤선옥 ( Yoon Sun-Och )
서울대학교 의과대학 병리학교실
전윤경 ( Jeon Yoon-Kyung )
서울대학교 의과대학 병리학교실
김철우 ( Kim Chul-Woo )
서울대학교 의과대학 병리학교실
김지은 ( Kim Ji-Eun )
서울대학교 의과대학 보라매병원 병리과
KMID : 0357920090430040312
Abstract
Background : The association of simian virus 40 (SV40) with certain types of human cancers, including malignant lymphomas, has been a topic of interest for some time. Although the virus is distributed worldwide, its incidences vary according to the specific types of tumors, and the epidemiological areas. The aim of this study was to investigate the frequency of SV40 in malignant lymphomas among Korean patients.
Methods : One hundred seventy three cases of malignant lymphomas were evaluated by immunohistochemical staining for SV40 large T antigen (TAg), using an extremely sensitive, tyramide based, catalyzed signal amplification method.
Results : From 158 non-Hodgkin`s lymphomas, including 115 diffuse large B-cell lymphomas, and 15 Hodgkin`s lymphomas, none of the cases were positive for SV40 TAg.
Conclusions : SV40 does not appear to be related to the pathogenesis of malignant lymphomas among Koreans.
키워드
Simian virus 40;Antigens;Polyomavirus transforming;Lymphoma;Korea
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