Expression of p63 and its Isoform, deltaNp63, in Non-Small Cell Lung Carcinoma
김익두, 신동훈, 최경운, 박도윤, 허기영, 설미영, 이민기, 김영대, 이창훈,
소속 상세정보
김익두 ( Kim Ick-Doo )
부산대학교 의과대학 병리학교실
신동훈 ( Shin Dong-Hoon )
부산대학교 의과대학 병리학교실
최경운 ( Choi Kyung-Un )
부산대학교 의과대학 병리학교실
박도윤 ( Park Do-Youn )
부산대학교 의과대학 병리학교실
허기영 ( Huh Gi-Yeong )
부산대학교 의과대학 병리학교실
설미영 ( Sol Mee-Young )
부산대학교 의과대학 병리학교실
이민기 ( Lee Min-Ki )
부산대학교 의과대학 내과학교실
김영대 ( Kim Young-Dae )
부산대학교 의학전문대학원 흉부외과학교실
이창훈 ( Lee Chang-Hun )
부산대학교 의과대학 병리학교실
KMID : 0357920090430040321
Abstract
Background : Several studies have been conducted on the role of the p63 gene family in non- small cell lung carcinoma (NSCLC). Nevertheless, the role of these genes in the development and progression of NSCLC remains controversial. This study was designed to examine the expression and clinicopathologic significance of the p63 family in NSCLC.
Methods : Immunohistochemical staining was performed on 92 cases of NSCLC (47 squamous cell carcinomas [SqCCs] and 45 adenocarcinomas [ACs]) using tissue microarray blocks. The results were analyzed and correlated with clinicopathologic data.
Results : The expression of deltaNp63 (△Np63) was elevated in SqCC (39/47), but not in AC (2/45; p<0.01). Both p63 and △Np63 had high expression in 39 SqCCs; p63 and △Np63 also had a similar geomorphologic distribution in most positive tumors. The expression of △Np63 was correlated with histologic type, gender, pT stage, p53 expression, and p63 expression. pT and pN stages were independent factors in survival (p<0.05, respectively).
Conclusions : The major p63 isoform in NSCLC, △Np63, had a strong correlation with p53 and p63, and was exclusively expressed in SqCC. However, our findings suggest that △Np63 was not an independent prognostic factor for NSCLC.
키워드
Carcinoma;Non-small cell lung;Carcinoma;Squamous cell;DeltaNp63 protein;p63 tumor suppressor protein;Immunohistochemistry
원문 및 링크아웃 정보
등재저널 정보