Expression of Survivin in Gastric Carcinoma and its Relation to Tumor Cell Proliferation and Apoptosis
이완식, 조성범, 류종선, 이제혁, 박창수, 주영은,
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이완식 ( Lee Wan-Sik )
전남대학교 의과대학 내과학교실
조성범 ( Cho Sung-Bum )
전남대학교 의과대학 내과학교실
류종선 ( Rew Jong-Sun )
전남대학교 의과대학 내과학교실
이제혁 ( Lee Jae-Hyuk )
전남대학교 의과대학 병리학교실
박창수 ( Park Chang-Soo )
전남대학교 의과대학 병리학교실
주영은 ( Joo Young-Eun )
전남대학교 의과대학 내과학교실
KMID : 0357920090430040329
Abstract
Background : Survivin, a novel antiapoptotic gene has been linked with tumor development and progression in various human carcinomas including gastric carcinomas. The aim of this study was to evaluate the expression of survivin in gastric carcinoma and its correlation with tumor cell proliferation and apoptosis.
Methods : Expression of survivin was evaluated immunohistochemically in 84 surgically resected gastric carcinomas. Tumor cell apoptosis was evaluated with terminal deoxynucleotidyl transferase (TdT) mediated deoxyuridine triphosphate (dUTP) nick-end labeling (TUNEL), and Ki-67 immunostaining was used for evaluation of tumor cell proliferation.
Results : Expression of survivin was noted in 53.6% of the gastric carcinomas, and was significantly associated with depth of invasion, status of lymph node metastasis or tumor stage (p=0.022, 0.034, 0.040, respectively). There was an inverse correlation between survivin expression and apoptotic index (p=0.015). But there was no significant correlation between survivin expression and Ki-67 labeling index (p=0.430).
Conclusions : These results suggest that survivin expression may contribute to tumor development and progression by inhibiting apoptosis in human gastric carcinoma.
키워드
BIRC5 protein;Cell proliferation;Apoptosis;Stomach neoplasms
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