Malignant Glomus Tumors of the Stomach - A Report of 2 Cases with Multiple Metastases -
이현주, 최윤석, 오상철, 박종재, 김철환, 김한겸, 김인선,
소속 상세정보
이현주 ( Lee Hyun-Joo )
고려대학교 의과대학 병리학교실
최윤석 ( Choi Yoon-Seok )
고려대학교 의과대학 종양혈액내과학교실
오상철 ( Oh Sang-Cheul )
고려대학교 의과대학 종양혈액내과학교실
박종재 ( Park Jong-Jae )
고려대학교 의과대학 소화기내과
김철환 ( Kim Chul-Whan )
고려대학교 의과대학 병리학교실
김한겸 ( Kim Han-Kyeom )
고려대학교 의과대학 병리학교실
김인선 ( Kim In-Sun )
고려대학교 의과대학 병리학교실
KMID : 0357920090430040358
Abstract
Glomus tumors are mesenchymal neoplasms usually developing in the dermis or subcutis of the extremities. The majority of glomus tumors are entirely benign, and malignant glomus tumors are very rare, especially those arising in the visceral organs. Here, we are presenting two cases of malignant glomus tumor, initially diagnosed in the stomach by endoscopic biopsy. Case 1 was found in the stomach, right kidney, brain and humerus of a 65-year-old woman, and Case 2 in the stomach and liver of a 63-year-old man. Histologically, the tumor was composed of solid sheets and nests of round and short-spindle shaped tumor cells with vesicular nucleus and prominent nucleolus. The tumor cells were closely admixed with blood vessels of varying size. Immunohistochemically, the tumor cells showed diffuse and strong positive staining for smooth muscle actin and paranuclear, dot-like staining for synaptophysin, but negative for desmin, c-kit, CD34 and S-100 protein. These two are rare cases of a malignant glomus tumor with widespread metastases.
키워드
Glomus tumor;Stomach;Kidney;Brain;Neoplasm metastasis
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