Morphological Features of Metastatic Gastrointestinal Stromal Tumors after Gleevec Treatment - Two Cases Report -
최준혁, 배영경, 송선교, 김홍진, 심민철, 이경희,
소속 상세정보
최준혁 ( Choi Joon-Hyuk )
영남대학교 의과대학 병리학교실
배영경 ( Bae Young-Kyung )
영남대학교 의과대학 병리학교실
송선교 ( Song Sun-Kyo )
영남대학교 의과대학 외과학교실
김홍진 ( Kim Hong-Jin )
영남대학교 의과대학 외과학교실
심민철 ( Shim Min-Chul )
영남대학교 의과대학 외과학교실
이경희 ( Lee Kyoung-Hee )
영남대학교 의과대학 내과학교실
KMID : 0357920090430040368
Abstract
We report two patients with metastatic gastrointestinal stromal tumors (GISTs) with a focus on the morphological features related to Gleevec treatment. In case 1, a 50-year-old woman presented with a 1.8 cm metastatic GIST in the liver after resection of a gastric GIST. Majority of the metastatic tumor showed fibrosis and hyalinization after 8 weeks of Gleevec treatment. CD117-positive cells were present in approximately 1% of the overall tumor. In case 2, a 2 cm and 14 cm metastatic liver masses were found in a 54-year-old man who had a rectal GIST. After 4 weeks of Gleevec treatment, metastatic tumors showed a decrease in size on CT scan. The metastatic tumors showed a decrease in number of tumor cells. The hemorrhage, cystic changes, necrosis, and fibrosis made up approximately 90% of the tumor. The morphological features related to Gleevec treatment are important for correct diagnosis and evaluation of tumor response and prognosis.
키워드
Gastrointestinal stromal tumor;Gleevec;Liver;Metastasis;Morphology
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