Gastrointestinal Stromal Tumor of the Colon Mimicking Inflammatory Fibroid Polyp with a Novel 63 bp c-kit Deletion Mutation - A Case Report -
도인구, 박철근, 윤성현, John Goldblum, 김경미,
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도인구 ( Do In-Gu )
성균관대학교 의과대학 삼성서울병원 병리학교실
박철근 ( Park Cheol Keun )
성균관대학교 의과대학 삼성서울병원 병리학교실
윤성현 ( Yoon Sung-Hyun )
성균관대학교 의과대학 삼성서울병원 외과
( John Goldblum )
USA Cleveland Clinic Department of Anatomic Pathology
김경미 ( Kim Kyoung-Mee )
성균관대학교 의과대학 삼성서울병원 병리학교실
KMID : 0357920090430040374
Abstract
Colonic gastrointestinal stromal tumors (GISTs) are rare and behave aggressively compared to GISTs in other parts of the gastrointestinal tract. Therefore, accurate diagnosis of GISTs and their distinction from other mesenchymal tumors is important for proper patient management and follow-up. Herein, we present an unusual case of a colonic GIST mimicking an inflammatory fibroid polyp with a novel 63 bp deletion mutation in exon 11 of the c-kit gene, which has not previously been reported. The tumor consisted of loosely arranged spindle cells and many inflammatory cells scattered throughout the tumor. Immunohistochemically, the tumor cells were focally and weakly positive for c-kit and diffusely positive for CD34, but were negative for PKC-theta, SMA, S-100 protein, ALK-1, and desmin. Our case re-emphasizes the broad morphologic spectrum of GISTs.
키워드
Gastrointestinal stromal tumors;Colonic polyp;c-kit;Mutation
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