체액 세포검사에서 고식적 세포도말검사와 CellprepPlus® 액상세포검사의 세포학적 평가 비교
Comparison of Cytologic Evaluation between Conventional Method and CellprepPlus® Liquid-Based Cytology in Body Fluid
구지혜, 이호창, 송형근, 한혜숙, 이기형, 최강현, 이기만, 이옥준,
소속 상세정보
구지혜 ( Koo Ji-Hae )
충북대학교 의과대학 병리학교실
이호창 ( Lee Ho-Chang )
충북대학교 의과대학 병리학교실
송형근 ( Song Hyung-Geun )
충북대학교 의과대학 병리학교실
한혜숙 ( Han Hye-Sook )
Chungbuk National University
이기형 ( Lee Ki-Hyeong )
Chungbuk National University
최강현 ( Choe Kang-Hyeon )
Chungbuk National University
이기만 ( Lee Kee-Man )
Chungbuk National University
이옥준 ( Lee Ok-Jun )
충북대학교 의과대학 병리학교실
KMID : 0357920090430050448
Abstract
Background: Assessment of body fluid cytology is a useful means of evaluating a metastatic tumor. Liquid-based cytology (LBC) has been developed as a replacement for the conventional Papanicolaou (CP) test. This study was performed to compare CellprepPlus® LBC with CP in cytologic diagnosis.
Methods: Body fluid samples (n=188, including 72 peritoneal fluid and 116 pleural fluid samples) were divided equally and analyzed by both CellprepPlus® and CP.
Results: CellprepPlus® revealed distributed thin layers of non-overlapping cells. All CellprepPlus® preparations were adequate, while 18 (9.57%) CP preparations were inadequate. The respective diagnostic rates of CellprepPlus® and CP were 75.0% and 76.1% negative, 10.6% and 6.38% atypical, 5.85% and 2.66% suspicious, and 8.51% and 5.32% malignant. Of the 58 confirmed cases, the sensitivity of CellprepPlus® and CP was 94.4% and 73.3%, respectively, and the negative predictive value was 97.2% and 87.9%, respectively.
Conclusions: CellprepPlus® LBC has better sensitivity and negative predictive value, and produces higher quality slide preparations than than CP, making it suitable as in screening of body fluid as a cytologic diagnostic tool.
키워드
Body fluids;Cytology;Neoplasm metastasis
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