Immunohistochemical and Molecular Characteristics of Follicular Patterned Thyroid Nodules with Incomplete Nuclear Features of Papillary Thyroid Carcinoma
민혜숙, 강경훈, 최기영, 조남윤, 박소연, 박성호,
소속 상세정보
민혜숙 ( Min Hye-Sook )
국립암센터 병리과
강경훈 ( Kang Gyeong-Hoon )
서울대학교 의과대학 병리학교실
최기영 ( Choe Ghee-Young )
서울대학교 의과대학 병리학교실
조남윤 ( Cho Nam-Yun )
서울대학교 의과대학 암연구소
박소연 ( Park So-Yeon )
서울대학교 의과대학 병리학교실
박성호 ( Park Seong-Hoe )
서울대학교 의과대학 병리학교실
KMID : 0357920090430060495
Abstract
Background: Follicular patterned thyroid nodules with incomplete nuclear features of papillary thyroid carcinoma (FTN-INPTCs) are difficult to diagnose, and their biological behavior and association with follicular variants of PTC (FVPTCs) have not yet been established. The aim of this study is to determine immunohistochemical and molecular characteristics of FTN-INPTCs.
Methods: We investigated immunohistochemical features (galectin-3, HBME-1, CK19, fibronectin-1, CITED1), BRAF V600E mutation and RASSF1A promoter methylation status in 30 FTN-INPTC cases, along with 26 FVPTCs, 21 follicular adenomas (FAs) and 14 nodular hyperplasias (NHs).
Results: Expression of galectin-3, HBME-1, CK19 and CITED1 was significantly higher in FTN-INPTCs than in FAs or NHs, but expression of galectin-3, CK19 and fibronectin-1 was lower in FTN-INPTCs than in FVPTCs. The BRAF V600E mutation was not detected in the benign nodules or FTN-INPTCs, whereas 57% of FVPTCs had the mutation. RASSF1A promoter methylation was higher in FTN-INPTCs than in benign nodules but there was no difference between FTN-INPTCs and FVPTCs.
Conclusions: Our results represent the borderline immunohistochemical and molecular characteristics of FTN-INPTC. We conclude that FTN-INPTC is an intermediate lesion between a benign nodule and a FVPTC, and that it is pathogenetically related to FVPTC.
키워드
Thyroid gland;Thyroid neoplasms;Carcinoma;Papillary
원문 및 링크아웃 정보
등재저널 정보